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Portrait of a man in his forties standing beside a window, the patient this men's testosterone replacement page is written for

Men's Hormone Replacement Therapy and TRT in Southlake, TX

Men's HRT restores testosterone when bloodwork confirms it has fallen too low. Most men come in for the fatigue, the workouts that stopped paying off and the flat mood.

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A confirmed number before any prescription

Testosterone falls gradually, so the symptoms arrive quietly: fatigue, lost strength, low libido and a flatter mood. Men’s HRT replaces what bloodwork shows is missing, using a route that fits your schedule. Dr. Mikki confirms the deficiency on a morning draw before prescribing, then monitors the labs testosterone actually moves.

What testosterone replacement addresses

Energy and drive

Low testosterone tracks with fatigue, low motivation and reduced libido. Replacement restores levels toward a healthy range when labs confirm a true deficiency.

Muscle and body composition

Testosterone supports lean muscle and influences fat distribution. Men on therapy often find strength work delivers results it stopped giving before.

Injections, cream or pellet

TRT is given as intramuscular injections, a daily transdermal cream, or pellets placed just under the skin. The route is matched to your labs, schedule and preference.

Monitored bloodwork

Dr. Mikki tracks testosterone, estradiol, red blood cell count and PSA on TRT. Monitoring is part of the plan because testosterone thickens the blood.

Low testosterone symptoms worth testing for

No item here confirms low testosterone, and none of them is treated on the strength of a list. They are the pattern worth bringing to a morning blood draw, which is what settles it.

What low testosterone looks like physically

These are the changes men usually notice first, and they are the ones a blood test can put a number against.

  • Fatigue and low energy
  • Loss of muscle mass
  • Increased body fat
  • Weight gain
  • Erectile dysfunction

What it looks like day to day

These arrive quietly and get blamed on work, sleep or age. They belong in the same conversation as the physical ones.

  • Low libido
  • Mood swings
  • Low mood
  • Brain fog
  • Loss of motivation

Testosterone delivery methods, compared

The hormone is the same molecule whichever way it arrives. What changes is how steadily it arrives and how much of the schedule falls to you. Pellet Therapy sits at the low-maintenance end, and the molecules used across every route here are bioidentical hormones.

Testosterone replacement delivery routes, how each is given and how often
Intramuscular injection How:The hormone is injected into muscle. Rhythm:Every two to four weeks.
Transdermal gel or patch How:A measured gel or an adhesive patch delivers hormone through the skin. Rhythm:Applied or worn daily.
Pellet implant How:A pellet is placed just under the skin in a short in-office visit, then releases hormone as it dissolves. Rhythm:One insertion covers several months.
Buccal tablet How:A tablet held against the gum, absorbed through the tissue of the mouth. Rhythm:On the schedule set at your consultation.
Ball-and-stick molecular model of a steroid hormone, with carbon, hydrogen and oxygen atoms shown as colored spheres joined by bonds
Testosterone is a steroid hormone, and that chemistry is why it is delivered by injection, gel, pellet or buccal tablet. Dr. Mikki picks the route with you at consultation.
Book a Consultation

Dr. Mikki orders the morning panel, reads it against your symptoms, and picks the route that fits your schedule. You leave knowing your own number and what the follow-up looks like.

How Medrein’s TRT compares with an online subscription

Men’s HRT is one route within the practice’s Hormone Replacement Therapy program. Pellet Therapy is the long-acting option when a steady release suits your routine better than a weekly schedule.

TRT at Medrein compared with an online testosterone subscription and doing nothing
Feature Men’s HRT (Medrein) Online Subscription No Treatment
Low testosterone confirmed on repeat labs Included Varies Not included
Hematocrit, estradiol and PSA monitored Included Varies Not included
Dose adjusted at follow-up Included Varies Not included
Fertility discussed before starting Included Varies Not included

Lab work and monitoring, step by step

1

Morning blood draw

Testosterone is measured on a morning draw, when levels peak, alongside your symptoms and your medical history.

2

Confirmation

A single low reading is confirmed with a repeat test. Symptoms without confirmed low labs are not treated with TRT here.

3

Route and start

You and Dr. Mikki choose the delivery route that fits your labs and your schedule, and therapy begins with a plan for the first follow-up already set.

4

Follow-up labs

Testosterone, estradiol, PSA and hematocrit are rechecked on a schedule. Hematocrit is your red blood cell concentration, and it is on that list because testosterone raises it.

5

Adjustment

The dose is adjusted against those labs and against how you actually feel. Levels are rechecked before each change.

Is TRT safe?

How the practice keeps it monitored

  • Bloodwork confirms low testosterone before therapy starts.
  • Hematocrit, estradiol and PSA are rechecked on a set schedule for as long as you are on therapy.
  • Fertility is discussed before you begin, because testosterone therapy can lower sperm production.
  • The dose is adjusted at follow-up as your labs change.
  • Dr. Mikki, a board-certified physician, writes every prescription herself.

Possible side effects

  • Fluid retention.
  • Acne.
  • An increased red blood cell count, which is why hematocrit is monitored.
  • Slight changes in cholesterol levels.
  • Reduced sperm production, which matters if you want to conceive.

Who men’s HRT is for

Dr. Mikki confirms candidacy against your labs and your history, and will say plainly when testosterone is not the explanation. Sometimes the honest next step is Medical Weight Loss or Peptide Therapy.

A good fit

  • Testosterone confirmed below a healthy range on a morning blood draw.
  • Symptoms that match those labs: fatigue, low libido, lost muscle, mood changes or brain fog.
  • Wanting a plan built from your own bloodwork and adjusted at follow-up visits.
  • Willing to return for repeat labs so the dose can be adjusted.

Not the right treatment

  • Symptoms with normal testosterone on repeat testing. The numbers guide the decision here.
  • Actively trying to conceive, unless a fertility-supporting plan is discussed first.
  • Certain prostate and heart histories, which Dr. Mikki reads before prescribing.
  • Unwilling to attend monitoring, because the risk on testosterone comes from going unmonitored.

Before you book, three things worth knowing

Insurance coverage varies by provider and plan, so check with your insurer for your own numbers. Energy and libido often shift within the first several weeks while changes in muscle and body composition take longer, and results may vary. And if you want to conceive, let Dr. Mikki know at the first visit. Testosterone therapy can lower sperm production, and there are fertility-supporting alternatives.

Book a Consultation

The consultation starts with your symptoms and your history, then the morning panel that settles whether testosterone is actually the cause. Nothing is prescribed until a repeat draw confirms it.

Testosterone measured when levels peak
Injection, gel or patch, pellet or buccal tablet
Testosterone therapy can lower sperm production
Dr. Mikki’s clinical foundation before aesthetics

Why men choose Medrein for TRT

These illustrate common patient sentiment. They are not word-for-word quotes, and individual results vary.

I was tired all the time, my workouts had stalled, and I assumed it was just age. Dr. Mikki ran a full panel, confirmed my testosterone was genuinely low, and walked me through the monitoring before I started. Results may vary, but the difference in energy over a few months was real, and I trusted that someone was watching my labs.

D.R., Men’s HRT patient, Southlake, TX

She checked my bloodwork properly instead of just handing me a vial. That is why I stayed.

J.T., TRT patient, Keller, TX
Dr. Haritha Mikkilineni, MD, in the reception area of the Medrein Health clinic in Southlake, TX
Dr. Mikki at the Medrein clinic in Southlake, TX
4.8★ 128 verified reviews

Frequently asked questions

What is men’s hormone replacement therapy?

Men’s HRT, also called testosterone replacement therapy or TRT, restores testosterone in men whose levels have fallen below a healthy range and who have symptoms to match. It targets fatigue, low libido, loss of muscle, mood changes and brain fog. Dr. Mikki confirms low testosterone on bloodwork before starting therapy.

How do I know if I need hormone replacement therapy?

If you are experiencing symptoms such as fatigue, low libido, weight gain, mood swings, brain fog or muscle loss, a blood test can determine whether your testosterone or other hormone levels are low. Dr. Mikki draws that panel in the morning, when testosterone peaks, and reads it alongside your history. A single low reading is confirmed with a repeat test. Symptoms without confirmed low labs are not treated with TRT, because the numbers guide the decision.

What are the benefits of HRT for men?

TRT can help improve energy levels, muscle mass, libido, mood, cognitive function and overall well-being, while reducing fatigue and body fat. Which of these change, and by how much, depends on your labs, your training and your starting point. Results may vary from man to man.

How is TRT given?

The common routes are intramuscular injection every two to four weeks, a transdermal gel or patch used daily, long-acting pellets placed under the skin that cover several months, and a buccal tablet absorbed through the gum. Each has a different rhythm of dosing and monitoring. Pellet Therapy is the option when a steady, low-maintenance route suits you.

What monitoring does TRT require?

Testosterone raises hematocrit, the concentration of red blood cells, so it is checked on a schedule along with estradiol and PSA. Dr. Mikki adjusts the dose based on these labs and your response. TRT is an ongoing, monitored therapy for as long as you stay on it.

Is hormone replacement therapy safe for men?

When monitored by a healthcare provider, TRT is generally considered safe, though potential effects include fluid retention, acne, an increased red blood cell count, or slight changes in cholesterol levels. Those are the reasons the monitoring schedule exists, and Dr. Mikki reviews your own history against them before therapy begins.

Does TRT affect fertility?

Testosterone therapy can lower sperm production, which matters for men who want to conceive. There are alternative protocols that support fertility, and Dr. Mikki discusses this before you begin so the plan fits your goals. Results may vary by individual.

Does insurance cover hormone replacement therapy for men?

Coverage varies by provider and plan, so it is best to check with your insurance company to determine whether TRT is covered under your policy. Cost also depends on the delivery route you choose, so ask for the specifics at consultation.

Find out whether your testosterone is actually low

Dr. Mikki orders the morning panel, confirms the result on a repeat draw, and reviews your history before anything is prescribed.

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